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Due to COVID-19 this study is currently on hold

OAS

An observational study to measure biomarkers, inflammation, and mediators from healthy volunteers and participants with airways disease at stable state and during acute exacerbation. 

The purpose of this study is to understand more about conditions such as asthma, COPD, bronchiectasis and nasal polyps (conditions we often call ‘airways diseases’). We do not fully understand the mechanisms which cause these airways diseases and performing this research we hope will allow us to design better treatments for patients. We aim to build up a detailed picture of participants airways and how they are working

A key aspect of the work is to compare participants without these conditions to participants with the condition, to try to determine why some people are affected while others aren’t. In order to do this we need to recruit people who do not have airways diseases (as ‘healthy controls’) too.

We would also like to examine how these conditions affect patients and to do this we will look to collect information both when patients are stable and when they are undergoing an exacerbation, or flare, of their respiratory problems. Doing this may allow us to work out why people have exacerbations, and what might be done in future to prevent these.

Another aspect is to work out what happens to patients when we give a treatment. In many cases though we know that treatments work, we often do not know exactly how they work, and looking into this might help us better identify which patients are likely to respond to which treatments, and perhaps to come up with new treatments too. We will not give any trial medications as part of this study but if as part of your normal care your medications are changed it can be useful to collect detailed information on how you are before and after this change.