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Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation
20 December 2023
Propiogenic substrates and gut bacteria produce propionate, a post-translational protein modifier. In this study, we used a mouse model of propionic acidaemia (PA) to study how disturbances to propionate metabolism result in histone modifications and changes to gene expression that affect cardiac function. Plasma propionate surrogates were raised in PA mice, but female hearts manifested more profound changes in acyl-CoAs, histone propionylation and acetylation, and transcription. These resulted in moderate diastolic dysfunction with raised diastolic Ca2+, expanded end-systolic ventricular volume and reduced stroke volume. Propionate was traced to histone H3 propionylation and caused increased acetylation genome-wide, including at promoters of Pde9a and Mme, genes related to contractile dysfunction through downscaled cGMP signaling. The less severe phenotype in male hearts correlated with β-alanine buildup. Raising β-alanine in cultured myocytes treated with propionate reduced propionyl-CoA levels, indicating a mechanistic relationship. Thus, we linked perturbed propionate metabolism to epigenetic changes that impact cardiac function.
University will host numerous activities and openings for Oxford Open Doors 2023
15 September 2023
Oxford Open Doors will once again be a celebration of all things Oxford and, as ever, the University and its Colleges have planned an extensive programme as part of the event.
Blood clots during COVID-19 may be a cause of ongoing cognitive problems
15 September 2023
High levels of two proteins at the time of COVID-19 have been found in patients who later experienced cognitive problems, including ‘brain fog’, giving a major clue as to one cause of their symptoms: blood clots.
Oxford scientists honoured with four Royal Society Awards
15 September 2023
Each year, the Royal Society recognises exceptional research achievements by awarding a series of prestigious medals and prizes. Of the 25 awards for 2022-23, announced today, four honour Oxford University researchers for their outstanding contributions to science and medicine.
Important vaccinations
15 September 2023
All students (new and returning) are asked to ensure their vaccinations are up to date before arriving in Oxford ahead of the new academic year.
New model predicts ten year breast cancer risk
15 September 2023
A team of researchers at the University of Oxford, led by the Nuffield Department of Primary Care Health Sciences, have developed a new model that reliably predicts a woman's likelihood of developing and then dying of breast cancer within a decade.
A-level results: Congratulations to Oxford's new students
15 September 2023
Thousands of students from across the UK have been celebrating their exam results. The University of Oxford is delighted to congratulate the many students who have successfully met their Oxford offer, and whose places have been confirmed. Oxford's Vice-Chancellor, Professor Irene Tracey, said, 'Congratulations to all students who have received their results, particularly those who have had their offers to study at Oxford confirmed. We know that a considerable amount of hard work and dedication has got you to this point, and you should be rightly proud of your achievements. We look forward to welcoming you in October, and sharing everything Oxford has to offer.' Here we meet some of the students who will soon be joining us at Oxford.
New study offers hope in early detection of oesophageal cancer
15 September 2023
Researchers at Oxford University's Nuffield Department of Primary Care Health Sciences have developed a new tool to predict people’s risks of getting oesophageal cancer in the next ten years.
Nanopore technology achieves breakthrough in protein variant detection
7 August 2023
A team of scientists led by the University of Oxford have achieved a significant breakthrough in detecting modifications on protein structures. The method, published in Nature Nanotechnology, employs innovative nanopore technology to identify structural variations at the single-molecule level, even deep within long protein chains.
Oxford University team wins national teaching award
4 August 2023
The work of Oxford University’s Oxford Simulation, Teaching and Research team (OxSTaR) had been recognised by a Collaborative Award for Teaching Excellence (CATE). The AdvanceHE award celebrates outstanding collaborative impact on teaching and learning and highlights the key role of teamwork in higher education.
COVID-19 measures reduced life-threatening invasive bacterial infections
1 August 2023
Containment measures introduced to prevent the spread of SARS-CoV-2 resulted in a sustained reduction in the transmission of certain bacteria that cause diseases such as meningitis, sepsis and pneumonia, according to a new study published in The Lancet Digital Health by the Invasive Respiratory Infection Surveillance (IRIS) Consortium.
Science Together celebrates a second successful year of community-led research collaborations
1 August 2023
Last week, the University of Oxford’s historic Divinity School hosted a special evening event to celebrate the seven new community-led research collaborations formed over the last 12 months through the Science Together engagement programme.
Oxford R21/Matrix-M™ malaria vaccine receives regulatory clearance for use in Burkina Faso
31 July 2023
The University of Oxford-developed, Serum Institute of India PvT Ltd (SIIPL) manufactured and scaled up R21/Matrix-MTM malaria vaccine, leveraging Novavax’s adjuvant technology, has been licensed for use in Burkina Faso by the country’s regulatory agency, Agence Nationale de la Regulation Pharmaceutique (ANRP).
Oxford chemists achieve breakthrough achievement: hazard-free production of fluorochemicals
31 July 2023
For the first time, Oxford chemists have generated fluorochemicals – critical for many industries – without the use of hazardous hydrogen fluoride gas. The team’s innovative method, published this week in the leading journal Science, could achieve an immense impact in improving the safety and carbon footprint of a growing global industry.
Oxford to launch UK’s first trials unit dedicated to precision-prevention and early detection studies
31 July 2023
Oxford researchers have been given a £1 million boost to support their strategy of developing cancer prevention treatments and early diagnostic tools for people at high risk of cancer.
Routine brain scanning may improve clinical care for people with psychosis
31 July 2023
Routine brain scanning in people experiencing psychosis could help to identify underlying physical conditions that are causing their symptoms, according to a new study.
Participating in genetic studies is in your genes: Oxford study
31 July 2023
Why do some people take part in genetic studies while others do not? The answer may lie within our genetic makeup. According to a ground-breaking study by Oxford's Leverhulme Centre for Demographic Science and Big Data Institute, people who participate in genetic studies are genetically more likely to do so, leaving detectable ‘footprints’ in genetics data. This breakthrough equips researchers with the ability to identify and address participation bias, a significant challenge in genetic research.
Study reveals new mechanism for rapid evolution of multi-drug resistant infections in patients
31 July 2023
A research study led by the University of Oxford provides a transformational new insight into how antimicrobial resistance (AMR) emerges in patients with bacterial infections. The findings, published today in the journal Nature Communications, could help develop more effective interventions to prevent AMR infections developing in vulnerable patients.
African Phase I HIV vaccine trial shows encouraging preliminary results
31 July 2023
The multisite Phase I HIV-CORE 006 HIV vaccine clinical trial, run by the Globally Relevant AIDS Vaccine Europe-Africa Trials Partnership (GREAT), has concluded successfully.
Oxford conference to prepare for future of pandemics
28 July 2023
Representatives from academia, industry, policy and civil society are gathering in Oxford next week to discuss the latest scientific advances that are ensuring the world is better prepared for future pandemics.