Clinical Research Fellow
My research focuses on the development and implementation of digital pathology techniques to profile immune cell infiltrates in cancer. More specifically, I am interested in how different immune cell subsets are spatially arranged in relation to hypoxic regions within human solid tumours and whether the tumour microenvironment can be manipulated in order to encourage infiltration of anti-tumour effector immune cells.
I graduated from the University of Edinburgh Medical School in 2009 and, thereafter, have worked in Oxford. I am currently studying for a DPhil in Clinical Medicine, having taken time out from post-graduate training in Histopathology.
Recent advances in the biology of tumour hypoxia with relevance to diagnostic practice and tissue-based research.
Macklin PS. et al, (2020), The Journal of pathology, 250, 593 - 611
Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells
Barnkob MB. et al, (2019)
CM-Path Molecular Diagnostics Forum—consensus statement on the development and implementation of molecular diagnostic tests in the United Kingdom
Macklin PS. et al, (2019), British Journal of Cancer, 121, 738 - 743
Tumour seeding of the renal tumour biopsy tract – a histologically under‐recognised feature?
Macklin PS. et al, (2019), Histopathology
Systemic silencing of Phd2 causes reversible immune regulatory dysfunction
Yamamoto A. et al, (2019), Journal of Clinical Investigation, 129, 3640 - 3656