BSc BVSc MRCVS
DPhil Student - NDM
As a member of Persephone Borrow's HIV immunology group, my DPhil focuses on the role of cytokines of the TGF-β superfamily in HIV-1 infection.
Type I interferons, another family of innate cytokines, are known to mediate antiviral activity that restricts HIV-1 replication and impairs virus transmission; and are also involved in driving immune activation and apoptosis, contributing to HIV-1 pathogenesis. Previous work from the Drakesmith lab (MRC WIMM) has demonstrated parallels between the type I interferon system and the SMAD system (the canonical signalling pathway of TGF-β superfamily ligands), and has shown that they intersect at both the level of signalling and downstream gene expression, with implications for innate antiviral immunity. I am addressing the induction of TGF-β superfamily cytokines during HIV-1 infection, and their putative roles in HIV-1 control and pathogenesis.
I am a qualified vet and member of the Royal College of Veterinary Surgeons. I maintain clinical work alongside my DPhil.