Contact information
Katherine England
Postdoctoral Researcher
Katherine completed an M.Chem. degree at the University of Oxford, working under the supervision of Prof. Jeremy Robertson for her final year research project. In 2002, she joined the Medicinal Chemistry department at Pfizer in Sandwich, UK, where she worked in drug discovery across a variety of disease areas and drug classes. Katherine joined the Structural Genomics Consortium at the University of Oxford in 2011, where she designed and synthesized inhibitors of epigenetic proteins and was awarded a D.Phil. in Organic Chemistry under the supervision of Prof. Christopher Schofield and Prof. Paul Brennan.
In 2015, she joined the newly formed Alzheimer’s Research UK Oxford Drug Discovery Institute, where she is part of a multi-disciplinary research team working on target identification and drug discovery for dementia.
Recent publications
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Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
Preprint
O’Brien DP. et al, (2022)
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USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation
Journal article
Rusilowicz-Jones EV. et al, (2020), Life Science Alliance, 3, e202000768 - e202000768
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C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Journal article
Le Bihan Y-V. et al, (2019), European journal of medicinal chemistry, 177, 316 - 337
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Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells
Journal article
Tumber A. et al, (2017), Cell Chemical Biology, 24, 371 - 380
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Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
Journal article
Jones P. et al, (2017), Journal of Medicinal Chemistry, 60, 767 - 786