5-Methylcytosine (5mC) in DNA is an important epigenetic modification that is involved in diverse biological processes ranging from development to disease. With the recently developed bisulphite-free technology TAPS, it’s very promising that we could profile methylation signatures in cell-free DNA and other low-input samples. I’m very interested in utilising this latest technique to explore biomarkers for early cancer detection.
2018.05-2018-12: Shanghai Institute of Plant Physiology and Ecology, Research Assistant.
2013.09-2018.05: Shanghai Institute of Plant Physiology and Ecology, Ph.D.
Subtraction-free and bisulfite-free specific sequencing of 5-methylcytosine and its oxidized derivatives at base resolution
Liu Y. et al, (2021), Nature Communications, 12
Cell-free DNA TAPS provides multimodal information for early cancer detection.
Siejka-Zielińska P. et al, (2021), Science advances, 7