Emma Murphy
Assay Development and Screening Team Leader
Emma received her PhD in Biochemistry from the University of Leicester where she studied the function and mechanism of heme peroxidases and the engineered introduction of novel catalytic activities. Emma continued working on biophysical characterisation of peroxidases as a postdoctoral researcher at University College London before moving to the University of Colorado. Here Emma used a combination of high-throughput in silico and medium-throughput biophysical screening to discover novel compounds that bind to and disrupt the normal functioning of mosquito odorant binding proteins. Emma joined the ODDI in 2015 as an assay development and screening scientist and since 2018 Emma has led the assay development and screening team who develop and run biochemical and biophysical high-throughput screening assays. The team aims to identify chemical matter as tool compounds to validate novel neurodegeneration targets and as potential leads for therapeutic intervention.
Recent publications
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A novel high-content imaging-based technique for measuring binding of Dickkopf-1 to low-density lipoprotein receptor-related protein 6
Journal article
Priestley RS. et al, (2019), Journal of Pharmacological and Toxicological Methods, 95, 47 - 55
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A novel high-content imaging-based technique for measuring binding of Dickkopf-1 to low-density lipoprotein receptor-related protein 6.
Journal article
Priestley RS. et al, (2018), J Pharmacol Toxicol Methods
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Discovery of a PCAF Bromodomain Chemical Probe
Journal article
Moustakim M. et al, (2017), Angewandte Chemie International Edition, 56, 827 - 831
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Neutron cryo-crystallography captures the protonation state of ferryl heme in a peroxidase
Journal article
Casadei CM. et al, (2014), Science, 345, 193 - 197
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A novel mechanism of ligand binding and release in the odorant binding protein 20 from the malaria mosquitoAnopheles gambiae
Journal article
Ziemba BP. et al, (2013), Protein Science, 22, 11 - 21