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The bacterium Deinococcus radiodurans exhibits an extreme resistance to ionizing radiation. A small subset of Deinococcus genus-specific genes were shown to be up-regulated upon exposure to ionizing radiation and to play a role in genome reconstitution. These genes include an SSB-like protein called DdrB. Here, we identified a novel protein encoded by the dr1245 gene as an interacting partner of DdrB. A strain devoid of the DR1245 protein is impaired in growth, exhibiting a generation time approximately threefold that of the wild type strain while radioresistance is not affected. We determined the three-dimensional structure of DR1245, revealing a relationship with type III secretion system chaperones and YbjN family proteins. Thus, DR1245 may display some chaperone activity towards DdrB and possibly other substrates.

Original publication

DOI

10.1371/journal.pone.0056558

Type

Journal article

Journal

PLoS One

Publication Date

2013

Volume

8

Keywords

Amino Acid Sequence, Bacterial Proteins, Bacterial Secretion Systems, Base Sequence, Deinococcus, Models, Molecular, Molecular Chaperones, Molecular Sequence Data, Mutation, Protein Binding, Protein Conformation, Radiation Tolerance, Sequence Alignment