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A mild calcium catalysed Beckmann rearrangement has been realised, which forgoes the more traditional harsh reactions conditions associated with the transformation. The catalyst system is shown to be tolerant towards a wide variety of functional groups relevant to natural product synthesis and medicinal chemistry and the synthetic utility of the reaction has also been investigated. A preliminary mechanistic investigation was performed to understand the nature of the incoming nucleophile and a possible reaction pathway is described.

Original publication

DOI

10.1039/c7cc09491d

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

16/01/2018

Volume

54

Pages

654 - 657