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The discovery of the PS proteins, the complexities of their biochemistry and their potential involvement in signalling pathways and in apoptosis have galvanized research into AD. To date, the aspect of the functionality of the PSs most relevant to the pathology of AD is the effect of PS FAD mutants to increase the proportion of A beta 42 produced from cells. This, coupled to the observation that gamma-secretase cleavage is considerably reduced in neurons derived from PS-1 knockout mice, argues strongly that PS plays a very direct role in the proteolytic processing of APP.

Type

Journal article

Journal

Biochem Soc Trans

Publication Date

08/1998

Volume

26

Pages

491 - 496

Keywords

Alzheimer Disease, Amino Acid Sequence, Animals, Cell Membrane, Humans, Membrane Proteins, Mice, Mice, Knockout, Models, Molecular, Molecular Sequence Data, Neurons, Point Mutation, Presenilin-1, Presenilin-2, Protein Conformation, Signal Transduction