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The interaction of immunoglobulin E and otherwise harmless antigens (allergens) leads in sensitized individuals through effector cell activation to the immediate induction of a cascade of inflammatory reactions, the hallmark of type I allergy. Recently, the molecular and structural characterization of allergens, specific IgE antibodies and their epitopes has made rapid progress. Here we discuss active and passive strategies for therapy of type I allergy, which are based on interfering with the IgE-allergen interaction.

Original publication

DOI

10.1159/000023942

Type

Journal article

Journal

Int Arch Allergy Immunol

Publication Date

07/1998

Volume

116

Pages

167 - 176

Keywords

Allergens, Animals, Antigen-Antibody Reactions, Epitopes, B-Lymphocyte, Humans, Hypersensitivity, Immunoglobulin E, Vaccination