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Recent findings with a rhesus monkey cytomegalovirus based simian immunodeficiency virus vaccine have identified strong CD8+ T cell responses that are restricted by MHC-E. Also mycobacteria specific CD8+ T cells, that are MHC-E restricted, have been identified. MHC-E therefore can present a wide range of epitope peptides to CD8+ T cells, alongside its well defined role in presenting a conserved MHC-class I signal peptide to the NKG2A/C-CD94 receptor on natural killer cells. Here we explore the antigen processing pathways involved in these atypical T cell responses.

Original publication

DOI

10.1016/j.coi.2017.04.009

Type

Journal article

Journal

Curr Opin Immunol

Publication Date

06/2017

Volume

46

Pages

75 - 81

Keywords

AIDS Vaccines, Animals, Antigen Presentation, CD8-Positive T-Lymphocytes, Epitopes, T-Lymphocyte, HIV, HIV Antigens, HIV Infections, Histocompatibility Antigens Class I, Host-Pathogen Interactions, Humans, T-Lymphocyte Subsets