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Malaria has been a major global health problem of humans through history and is a leading cause of death and disease across many tropical and subtropical countries. Over the last fifteen years renewed efforts at control have reduced the prevalence of malaria by over half, raising the prospect that elimination and perhaps eradication may be a long-term possibility. Achievement of this goal requires the development of new tools including novel antimalarial drugs and more efficacious vaccines as well as an increased understanding of the disease and biology of the parasite. This has catalyzed a major effort resulting in development and regulatory approval of the first vaccine against malaria (RTS,S/AS01) as well as identification of novel drug targets and antimalarial compounds, some of which are in human clinical trials.

Original publication

DOI

10.1016/j.cell.2016.07.055

Type

Journal article

Journal

Cell

Publication Date

20/10/2016

Volume

167

Pages

610 - 624

Keywords

Adaptive Immunity, Animals, Antimalarials, Communicable Disease Control, Culicidae, Disease Eradication, Drug Resistance, Erythrocytes, Global Health, Host-Parasite Interactions, Humans, Life Cycle Stages, Liver, Malaria Vaccines, Malaria, Falciparum, Merozoites, Plasmodium falciparum, Sporozoites, Vaccines, Synthetic