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Lymphocytes from an HLA-B7 DW2 homozygous multiparous woman, J.H., failed to respond in the mixed lymphocyte reaction to lymphocytes from her DW1 homozygous husband, W.H., and certain other homozygous typing cells. J.H. lymphocytes could suppress the response of HLA matched responders to W.H. This effect was shown to be radiosensitive and due to a T cell. The suppressor cell showed antigen specificity.

Type

Journal article

Journal

J Exp Med

Publication Date

01/08/1977

Volume

146

Pages

368 - 380

Keywords

Cells, Cultured, Epitopes, Female, HLA Antigens, Histocompatibility Antigens, Homozygote, Humans, Immunologic Techniques, Immunosuppression, In Vitro Techniques, Lymphocyte Culture Test, Mixed, Male, T-Lymphocytes, Time Factors