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In southern Uganda, only sporadic cases of serogroup A meningococcal disease have been reported since 2000. As part of an immunogenicity study of the tetravalent meningococcal polysaccharide vaccine, nasopharyngeal swab samples were collected twice, 4 weeks apart, from 2-19-year-old healthy individuals in Mbarara, Uganda. Only 15 (2.0%) of the 750 individuals carried meningococci asymptomatically. Most of the strains were non-serogroupable and none were serogroup A. However, two individuals carried a serogroup W135 strain, sequence type (ST)-11, similar to the clone that was responsible for the epidemic in Burkina Faso in 2002. Our study further demonstrates the geographical spread of serogroup W135 ST-11 strain and thus the potential epidemic risk.

Original publication

DOI

10.1016/j.trstmh.2006.01.004

Type

Journal article

Journal

Trans R Soc Trop Med Hyg

Publication Date

12/2006

Volume

100

Pages

1159 - 1163

Keywords

Adolescent, Adult, Carrier State, Child, Child, Preschool, Genotype, Humans, Infant, Neisseria meningitidis, Pharynx, Phenotype, Uganda