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The rationale for developing anti-HIV vaccines that stimulate cytotoxic T-lymphocyte responses is given. We argue that such vaccines will work, provided that attention is paid to the development of memory T-cell responses that are strong and preferably activated. Furthermore, the vaccine should match the prevailing virus clade as closely as possible. Vaccines will have to stimulate a wide range of responses, but it is not clear how this can be achieved.

Original publication

DOI

10.1038/nri779

Type

Journal article

Journal

Nat Rev Immunol

Publication Date

04/2002

Volume

2

Pages

283 - 291

Keywords

AIDS Vaccines, Acquired Immunodeficiency Syndrome, Animals, CD8-Positive T-Lymphocytes, Cytotoxicity, Immunologic, HIV, Humans