Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

A number of CD4+ T cell lines were compared for their ability to act as target cells for human immunodeficiency virus (HIV) infection in syncytium- and plaque-forming assays. MT-4 and C8166 cells were the most sensitive indicator cells for HIV- and simian immunodeficiency virus (SIV)-induced cytopathic effects, and gave rise to macroscopic (MT-4) and microscopic (C8166) plaques. The MT-4 plaque assay was evaluated for the measurement of HIV- and SIV-neutralizing antibodies.

Original publication




Journal article


J Gen Virol

Publication Date



70 ( Pt 12)


3327 - 3333


Animals, Antibodies, Viral, CD4-Positive T-Lymphocytes, Cell Line, Cytopathogenic Effect, Viral, HIV, HIV Antibodies, Humans, Immune Sera, Neutralization Tests, Simian Immunodeficiency Virus, Viral Plaque Assay