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A major problem in hepatitis C virus (HCV) immunotherapy or vaccine design is the extreme variability of the virus. We identified human monoclonal antibodies (mAbs) that neutralize genetically diverse HCV isolates and protect against heterologous HCV quasispecies challenge in a human liver-chimeric mouse model. The results provide evidence that broadly neutralizing antibodies to HCV protect against heterologous viral infection and suggest that a prophylactic vaccine against HCV may be achievable.

Original publication




Journal article


Nat Med

Publication Date





25 - 27


Animals, Antibodies, Monoclonal, Epitopes, Hepacivirus, Hepatitis Antibodies, Hepatitis C, Humans, Immunoglobulin G, Mice, Neutralization Tests, Rats, Species Specificity, Viral Hepatitis Vaccines