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Much of our current understanding of hepatitis C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed hepatoma cell lines. Recent evidence suggests that lipoproteins play a key role in the HCV life cycle and virus particles derived from the sera of infected patients exist in association with host lipoproteins. This report will review the literature on HCV replication in primary hepatocytes and transformed cell lines, focusing largely on host factors defining particle entry.

Original publication

DOI

10.1111/j.1365-2893.2008.01051.x

Type

Journal article

Journal

J Viral Hepat

Publication Date

12/2008

Volume

15

Pages

849 - 854

Keywords

Animals, Cell Line, Hepacivirus, Hepatitis C, Hepatocytes, Humans, Receptors, Lipoprotein, Receptors, Virus, Virus Replication