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The relevance of claudin-6 and claudin-9 in hepatitis C virus (HCV) entry remains elusive. We produced claudin-6- or claudin-9-specific monoclonal antibodies that inhibit HCV entry into nonhepatic cells expressing exogenous claudin-6 or claudin-9. These antibodies had no effect on HCV infection of hepatoma cells or primary hepatocytes. Thus, although claudin-6 and claudin-9 can serve as entry factors in cell lines, HCV infection into human hepatocytes is not dependent on claudin-6 and claudin-9.

Original publication

DOI

10.1128/JVI.01691-13

Type

Journal article

Journal

J Virol

Publication Date

09/2013

Volume

87

Pages

10405 - 10410

Keywords

Antibodies, Monoclonal, Cells, Cultured, Claudins, Hepacivirus, Hepatocytes, Humans, Virus Internalization