Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low oxygen or hypoxic environment. HIFs are regulated by oxygen-dependent and independent signals including: mitochondrial dysfunction, reactive oxygen species, endoplasmic reticular stress, and viral infection. HIFs have been reported to play a role in the pathogenesis of liver disease of diverse aetiologies. This review explores the impact of HIFs on hepatocellular biology and inflammatory responses, highlighting the therapeutic potential of targeting HIFs for an array of liver pathologies.

Original publication




Journal article


J Hepatol

Publication Date





1397 - 1406


HIF, Hypoxia, Inflammation, Liver, Viral hepatitis, Animals, Basic Helix-Loop-Helix Transcription Factors, Carcinoma, Hepatocellular, Disease Models, Animal, Hepatovirus, Humans, Hypoxia-Inducible Factor 1, Liver, Liver Diseases, Liver Neoplasms, Mice, Oxygen, Virus Diseases