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Although the roles of 5-methylcytosine and 5-hydroxymethylcytosine in epigenetic regulation of gene expression are well established, the functional effects of 5-formylcytosine and 5-carboxylcytosine on the process of transcription are not clear. Here we report a systematic study of the effects of five different forms of cytosine in DNA on mammalian and yeast RNA polymerase II transcription, providing new insights into potential functional interplay between cytosine methylation status and transcription.

Original publication

DOI

10.1038/nsmb.2346

Type

Journal article

Journal

Nat Struct Mol Biol

Publication Date

08/2012

Volume

19

Pages

831 - 833

Keywords

Amino Acid Sequence, Base Sequence, Catalytic Domain, Cytosine, DNA, DNA, Fungal, Epigenesis, Genetic, Humans, Kinetics, Molecular Sequence Data, RNA, RNA Polymerase II, RNA, Fungal, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Substrate Specificity, Transcription, Genetic