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A neuronal cell line, HT-22, is sensitive to glutamate cytotoxicity via a non-receptor mediated oxidative pathway. 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C, blocks this glutamate-induced cell death. Down-regulation of protein kinase C eliminates the protection against glutamate cytotoxicity afforded by TPA. The data suggest that protein kinase C activation blocks an early step in the cytotoxic pathway.

Type

Journal article

Journal

Brain Res

Publication Date

25/07/1994

Volume

652

Pages

169 - 173

Keywords

Animals, Cell Death, Cell Line, Cell Survival, Down-Regulation, Enzyme Activation, Excitatory Amino Acid Antagonists, Glutamic Acid, Hippocampus, Mice, Neurons, Phosphorylation, Protein Kinase C, Tetradecanoylphorbol Acetate