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The continual improvement in our ability to generate high resolution structural models of biological molecules has stimulated and supported innovative chemical biology projects that target increasingly challenging ligand interaction sites. In this review we outline some of the recent developments in chemical biology and rational ligand design and show selected examples that illustrate the synergy between these research areas.

Original publication

DOI

10.1016/j.chembiol.2015.12.005

Type

Journal article

Journal

Cell Chem Biol

Publication Date

21/01/2016

Volume

23

Pages

173 - 182

Keywords

Animals, Crystallography, X-Ray, Drug Design, Humans, Ligands, Models, Molecular, Proteins, Small Molecule Libraries