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Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airway diseases that have a high personal and social impact. They likely represent a continuum of different diseases that may share biological mechanisms (i.e. endotypes), and present similar clinical, functional, imaging and/or biological features that can be observed (i.e. phenotypes) which require individualised treatment. Precision medicine is defined as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic, or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations". In this Perspective, we propose a precision medicine strategy for chronic airway diseases in general, and asthma and COPD in particular.

Original publication

DOI

10.1183/13993003.01359-2015

Type

Journal article

Journal

Eur Respir J

Publication Date

02/2016

Volume

47

Pages

410 - 419

Keywords

Asthma, Humans, Inflammation, Phenotype, Precision Medicine, Pulmonary Disease, Chronic Obstructive