Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.
Skip to main content

Posttranslational modification of proteins by the small molecule ubiquitin is a key regulatory event, and the enzymes catalyzing these modifications have been the focus of many studies. Deubiquitinating enzymes, which mediate the removal and processing of ubiquitin, may be functionally as important but are less well understood. Here, we present an inventory of the deubiquitinating enzymes encoded in the human genome. In addition, we review the literature concerning these enzymes, with particular emphasis on their function, specificity, and the regulation of their activity.

Original publication

DOI

10.1016/j.cell.2005.11.007

Type

Journal article

Journal

Cell

Publication Date

02/12/2005

Volume

123

Pages

773 - 786

Keywords

Amino Acid Motifs, Animals, Chromatin, Endocytosis, Endopeptidases, Genome, Human, Humans, Hydrolases, Models, Molecular, Phylogeny, Proteasome Endopeptidase Complex, Protein Conformation, Protein Processing, Post-Translational, Substrate Specificity, Ubiquitin