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A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed to but uninfected with human immunodeficiency virus type 1 (HIV-1) did not reveal genetic variants associated with resistance to HIV-1 infection, beyond homozygosity for CCR5-Δ32. Since variation in HLA class I and KIR genes is not well interrogated by standard GWAS techniques, we tested whether these 2 loci were involved in protection from HIV-1 infection in the same hemophilia cohort, using controls from the general population. Our data indicate that HLA class I alleles, presence or absence of KIR genes, and functionally relevant combinations of the HLA/KIR genotypes are not involved in resistance to parenterally transmitted HIV-1 infection.

Original publication

DOI

10.1093/infdis/jiu214

Type

Journal article

Journal

J Infect Dis

Publication Date

01/10/2014

Volume

210

Pages

1047 - 1051

Keywords

HESN, HIV-1, HLA, KIR, hemophilia, Disease Resistance, Genetic Association Studies, HIV Infections, Hemophilia A, Histocompatibility Antigens Class I, Humans, Receptors, KIR