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Human influenza A virus-specific, cytotoxic T cells have been shown previously to recognize the virus nucleoprotein on infected cells. CTL preparations from four HLA B37-positive donors were shown to recognize a synthetic peptide that corresponded to amino acids 335-349 of the nucleoprotein sequence. Influenza-specific CTL from 10 donors of other HLA types failed to recognize this epitope. CD8+ CTL lines were derived from lymphocytes of two HLA B37-positive donors and used to show that the peptide was represented on virus-infected cells and to determine the probable boundaries of the epitope.

Type

Journal article

Journal

J Exp Med

Publication Date

01/11/1986

Volume

164

Pages

1397 - 1406

Keywords

Cell Line, Epitopes, HLA Antigens, HLA-B Antigens, HLA-B37 Antigen, Humans, Influenza A virus, Interleukin-2, Nucleoproteins, Phenotype, T-Lymphocytes, Cytotoxic, Viral Proteins