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Influenza-A-virus-specific, HLA-restricted, cytotoxic T-cell immunity, measured in 189 volunteers in the six years 1977-82, showed a sharp decline from 1978. It is shown that natural infection with influenza-A virus boosts cytotoxic T-cell memory. The decline in T-cell immunity is probably associated with the low prevalence of influenza-A-virus infection since 1978.

Type

Journal article

Journal

Lancet

Publication Date

01/10/1983

Volume

2

Pages

762 - 764

Keywords

Adolescent, Adult, Cytotoxicity, Immunologic, England, Female, Humans, Immunologic Memory, Influenza A virus, Influenza, Human, Male, Middle Aged, T-Lymphocytes, Cytotoxic