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SH2 domains are phosphotyrosine specific interaction modules with largely overlapping sequence specificities. A recent structure by Bae et al. revealed that SH2 domain specificity can be mediated by secondary binding sites located outside the phosphotyrosine binding pocket.

Original publication

DOI

10.1016/j.str.2009.07.002

Type

Journal article

Journal

Structure

Publication Date

12/08/2009

Volume

17

Pages

1040 - 1041

Keywords

Binding Sites, Mutation, Phosphotyrosine, Protein Binding, Signal Transduction, src Homology Domains