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An intercellular adhesion molecule-1 polymorphism (ICAM-1(Kilifi)) is present at a high frequency across sub-Saharan Africa, and its presence may increase susceptibility to cerebral malaria. Here, we report that, compared with children in whom wild-type intercellular adhesion molecule-1 is present, the incidence of nonmalarial fever is significantly lower among those homozygous for ICAM-1(Kilifi). We propose that ICAM-1(Kilifi) may be associated with reduced rates of tissue damage and of death due to sepsis.

Original publication

DOI

10.1086/498156

Type

Journal article

Journal

Clin Infect Dis

Publication Date

15/12/2005

Volume

41

Pages

1817 - 1819

Keywords

Fever, Humans, Incidence, Infant, Infection, Intercellular Adhesion Molecule-1, Kenya, Malaria, Polymorphism, Genetic