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Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.


Journal article


J Virol

Publication Date





10507 - 10511


Animals, CD4-Positive T-Lymphocytes, Cell Division, Epitopes, T-Lymphocyte, Gene Products, gag, Histocompatibility Antigens Class I, Humans, Immunodominant Epitopes, Macaca mulatta, Simian Immunodeficiency Virus, T-Lymphocytes, Cytotoxic, Vaccination