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CD8+ T cell responses can be generated against antigens that are not expressed directly within antigen-presenting cells (APCs), through a process known as cross-priming. To initiate cross-priming, APCs must both capture extracellular antigen and receive specific activation signals. We have investigated the nature of APC activation signals associated with virus infection that stimulate cross-priming. We show that infection with lymphocytic choriomeningitis virus induces cross-priming by a mechanism dependent on type I interferon (IFN-alpha/beta). Activation of cross-priming by IFN-alpha/beta was independent of CD4+ T cell help or interaction of CD40 and CD40 ligand, and involved direct stimulation of dendritic cells. These data identify expression of IFN-alpha/beta as a mechanism for the induction of cross-priming during virus infections.

Original publication

DOI

10.1038/ni978

Type

Journal article

Journal

Nat Immunol

Publication Date

10/2003

Volume

4

Pages

1009 - 1015

Keywords

Animals, Antigen Presentation, CD40 Antigens, CD40 Ligand, CD8-Positive T-Lymphocytes, Dendritic Cells, Female, Interferon Type I, Lymphocyte Activation, Lymphocytic Choriomeningitis, Lymphocytic choriomeningitis virus, Mice, Mice, Inbred C57BL, Mice, Knockout, Ovalbumin, Specific Pathogen-Free Organisms