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We sought genetic evidence for the importance of host-parasite interactions involving CD36 in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the influence of this mutation on the outcome of malaria infection in 693 African children with severe malaria and a similar number of ethnically matched controls. We showed that heterozygosity for this mutation is associated with protection from severe disease (OR 0.74, 95% CI 0.55-0.99; p=0.036). These findings suggest that this Cd36 mutation might have a complex effect on malaria infection by decreasing parasite sequestration, and also by decreasing host immune responses.

Original publication

DOI

10.1016/S0140-6736(00)04662-6

Type

Journal article

Journal

Lancet

Publication Date

12/05/2001

Volume

357

Pages

1502 - 1503

Keywords

CD36 Antigens, Child, Child, Preschool, Codon, Nonsense, Female, Genetic Carrier Screening, Host-Parasite Interactions, Humans, Infant, Kenya, Malaria, Cerebral, Malaria, Falciparum, Male