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Major histocompatibility complex class I B alleles, HLA B8, B53 and B3501 have been cloned, expressed, refolded and crystallized in specific complexes with a number of different 8-mer and 9-mer peptides. For some of these crystallization was initiated by cross-seeding between different B allele complexes. All crystallize in the space group P212121, with similar unit cell dimensions of approximately 52 A X 81 A X 112 A, contain one complex per asymmetric unit and diffract to approximately 2.0 A resolution.

Type

Journal article

Journal

FEBS Lett

Publication Date

25/03/1996

Volume

383

Pages

119 - 123

Keywords

Alleles, Amino Acid Sequence, Base Sequence, Cloning, Molecular, Crystallization, Crystallography, X-Ray, DNA Primers, Electrophoresis, Polyacrylamide Gel, Epitopes, Escherichia coli, Genes, MHC Class I, HLA Antigens, HLA-B8 Antigen, Humans, Molecular Sequence Data, Oligopeptides, Protein Conformation, Protein Folding, Recombinant Proteins