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In a longitudinal study of HIV seropositive patients, there were fluctuations in the specificity of cytotoxic T cells for the virus. This was matched by variability in proviral gag DNA epitope sequences in the lymphocytes of these patients. Some of these viral variants are not recognized by autologous T cells. Accumulation of such mutations in T-cell antigenic targets would provide a mechanism for immune escape.

Original publication

DOI

10.1038/354453a0

Type

Journal article

Journal

Nature

Publication Date

12/12/1991

Volume

354

Pages

453 - 459

Keywords

Amino Acid Sequence, Base Sequence, Epitopes, Genetic Variation, HIV, HIV Core Protein p24, HIV Infections, HIV Seropositivity, Hemophilia A, Humans, Longitudinal Studies, Molecular Sequence Data, Mutation, Peptide Fragments, T-Lymphocytes, Cytotoxic