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A mutation in the Duffy antigen (DARC) that abrogates receptor expression and gives profound protection against some malaria species has become almost universal in African populations. He et al. (2008) show that this polymorphism also leads to significantly increased susceptibility to HIV-1 infection but, paradoxically, to prolonged survival in HIV-1-infected subjects.

Original publication

DOI

10.1016/j.chom.2008.06.006

Type

Journal article

Journal

Cell Host Microbe

Publication Date

17/07/2008

Volume

4

Pages

3 - 5

Keywords

Chemokines, Disease Susceptibility, Duffy Blood-Group System, Erythrocytes, HIV, Humans, Models, Biological, Polymorphism, Genetic, Receptors, Cell Surface