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HLA-B5701 and its related allele B5703 have been shown to be strongly associated with slow HIV-1 disease progression. To elucidate the effect of these alleles fully on disease progression it is essential to identify key HIV-1 epitopes that are restricted by these alleles. Here we describe the identification of a novel HLA-B5701, B5703 restricted epitope within HIV-1 rev, which accounted for up to 25 and 40% of the total cytotoxic T-lymphocyte responses in two patients.

Original publication

DOI

10.1097/01.aids.0000206509.39654.8e

Type

Journal article

Journal

AIDS

Publication Date

14/02/2006

Volume

20

Pages

462 - 464

Keywords

Acute Disease, Chronic Disease, Disease Progression, Epitopes, T-Lymphocyte, HIV Infections, HIV-1, HLA-B Antigens, Humans, Immunity, Cellular, T-Lymphocytes, Cytotoxic