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To investigate African long-term survivors (LTSs) infected with non-subtype B human immunodeficiency virus type 1 (HIV-1), we obtained full-length HIV-1 RNA sequences and immunogenetic profiles from 6 untreated women enrolled in the Pumwani Sex Worker Cohort in Nairobi, Kenya. There were no discernible sequence changes likely to cause attenuation. CCR2-V64I, an immunogenetic polymorphism linked to LTSs, was detected in 4 women, all of whom carried the HLA B58 allele. Further investigation of 99 HIV-1-infected Nairobi women found an association between CCR2-V64I and HLA B58 (P=.0048). Studying the interaction among immunogenetics, immune responses, and viral sequences from all HIV-1 subtypes may increase our understanding of slow HIV-1 disease progression.

Original publication

DOI

10.1086/421504

Type

Journal article

Journal

J Infect Dis

Publication Date

15/08/2004

Volume

190

Pages

697 - 701

Keywords

Adult, Alleles, Chemokine CCL2, Cohort Studies, Female, Genotype, HIV Infections, HIV-1, HLA Antigens, Humans, Kenya, Molecular Sequence Data, Occupational Diseases, Polymorphism, Genetic, RNA, Viral, Receptors, CCR2, Receptors, Chemokine, Sex Work