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Certain human leukocyte antigens, by presenting conserved immunogenic epitopes for T cell recognition, may, in part, account for the observed differences in human immunodeficiency virus type 1 (HIV-1) susceptibility. To determine whether HLA polymorphism influences HIV-1 susceptibility, a longitudinal cohort of highly HIV-1-exposed female sex workers based in Nairobi, Kenya, was prospectively analyzed. Decreased HIV-1 infection risk was strongly associated with possession of a cluster of closely related HLA alleles (A2/6802 supertype; incidence rate ratio [IRR], 0.45; 95% confidence interval [CI], 0.27-0.72; P=.0003). The alleles in this supertype are known in some cases to present the same peptide epitopes for T cell recognition. In addition, resistance to HIV-1 infection was independently associated with HLA DRB1*01 (IRR, 0.22; 95% CI, 0.06-0.60; P=.0003), which suggests that anti-HIV-1 class II restricted CD4 effector mechanisms may play an important role in protecting against viral challenge. These data provide further evidence that resistance to HIV-1 infection in this cohort of sex workers is immunologically mediated.

Original publication

DOI

10.1086/315472

Type

Journal article

Journal

J Infect Dis

Publication Date

05/2000

Volume

181

Pages

1581 - 1589

Keywords

Acquired Immunodeficiency Syndrome, Adult, Cohort Studies, Confidence Intervals, Disease Susceptibility, Female, HIV Infections, HIV Seronegativity, HIV Seropositivity, HIV-1, HLA Antigens, HLA-DR Antigens, HLA-DRB1 Chains, Humans, Immunity, Innate, Kenya, Longitudinal Studies, Major Histocompatibility Complex, Polymorphism, Genetic, Sex Work, Time Factors