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The associations between serum parathyroid hormone (PTH), blood pressure and hypotensive medication were analysed in 282 renal transplant recipients. Among patients with a normal concentration of serum creatinine there was no correlation between serum PTH and blood pressure but in those receiving hypotensive medication serum PTH was appropriately twofold greater than in those not taking hypotensive medication. Analysis revealed that the dominant contribution to this association was a specific association with loop diuretic therapy. When all patients were stratified according to creatinine clearance, serum PTH was always greater in patients receiving loop diuretics but this difference was particularly striking in the patients with the poorest graft function. It is postulated that loop diuretics exacerbate the hyperparathyroidism which complicates renal disease.

Type

Journal article

Journal

Nephrol Dial Transplant

Publication Date

1989

Volume

4

Pages

740 - 744

Keywords

Adult, Blood Pressure, Creatinine, Diuretics, Female, Graft Rejection, Graft Survival, Humans, Hyperparathyroidism, Hypertension, Kidney Transplantation, Male, Middle Aged, Parathyroid Hormone, Prospective Studies