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Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.

Original publication

DOI

10.1128/IAI.69.2.1207-1211.2001

Type

Journal article

Journal

Infect Immun

Publication Date

02/2001

Volume

69

Pages

1207 - 1211

Keywords

Adolescent, Adult, Aged, Animals, Antibodies, Protozoan, Child, Child, Preschool, Humans, Immunoglobulin G, Infant, Merozoite Surface Protein 1, Middle Aged, Peptide Fragments, Plasmodium falciparum