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In previous studies of antigen presentation through HLA-B27, we identified a healthy person whose lymphoblastoid cells do not present three B27-restricted viral epitopes to specific cytotoxic T lymphocytes (CTL), despite adequate cell surface expression of HLA-B2702 of normal sequence. Similar findings were observed in all members of his family sharing the HLA-A3-B2702 haplotype. The original donor, NW, carries HLA-B8 on his other class I haplotype, which his daughter, HW, has inherited. We now report a failure to present an HLA-B8-restricted epitope from influenza nucleoprotein following viral infection of NW cells, although exogenous added peptide is still presented normally. However, cells from HW, which do not carry the A3-B2702 haplotype, present the expected epitope after viral infection. Another B8-restricted epitope, from human immunodeficiency virus-gag, is presented equally well by both cell lines when infected with gag-vaccinia. This antigen processing phenotype does not correlate with any of the known human TAP-1 and TAP-2 polymorphisms.

Original publication

DOI

10.1002/eji.1830230841

Type

Journal article

Journal

Eur J Immunol

Publication Date

08/1993

Volume

23

Pages

1999 - 2004

Keywords

ATP-Binding Cassette Sub-Family B Member 2, ATP-Binding Cassette Transporters, ATP-Binding Cassette, Sub-Family B, Member 3, Antigen-Presenting Cells, Carrier Proteins, Female, HLA-B8 Antigen, Histocompatibility Antigens Class II, Humans, Male, Nucleoproteins, Polymorphism, Genetic, RNA-Binding Proteins, T-Lymphocytes, Cytotoxic, Viral Core Proteins