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© 2017, Ibadan Biomedical Communications Group. All rights reserved. Human Leukocyte Antigen (HLA), particularly HLA-B and class II alleles have been differentially associated with disease outcomes in different populations following infection with the malaria Plasmodium falciparum. However, the effect of HLA-A on malaria infection and/or disease is not fully understood. Recently, HLA-A alleles have been suggested to play a role in the outcome of P. falciparum malaria infection in a Malian study. Herein, we investigated the association between HLA-A alleles and the outcome of malaria infection in children in Ibadan southwest Nigeria. HLA-A genotyping was performed on 393 children samples (DNA) using the sequence-based method. We compared genotype and allele frequencies data obtained from these Nigerian children; 176 with asymptomatic malaria infection (controls), 124 with uncomplicated malaria and 93 children with severe malaria (51 severe malarial anaemia and 42 cerebral malaria). We found a high frequency of HLA-A*36:01 (13.5%) in the entire studied population and also confirmed the high frequency of a previously reported allele of African origin (HLA-A*30:01). After adjusting for age and parasite density, we found a significant association between HLA-A*20:01:01 (OR = 3.19, p < 0.001) and susceptibility to severe malarial anaemia. We also found significant associations between HLA-A* 29:02:01 (OR = 7.26, p = 0.008) and A* 66:02 (Or = 4.19, p = 0.03) and susceptibility to cerebral malaria. Our findings suggest that HLA-A alleles play a role in the outcome of malaria in children in Ibadan. These findings may help elucidate the molecular background of malaria resistance in the study population.

Type

Journal article

Journal

African Journal of Biomedical Research

Publication Date

01/01/2017

Volume

20

Pages

223 - 228