Macrophages: micromanagers of antagonistic signaling nanoclusters
Eggeling C., Davis SJ.
<jats:p>How cells integrate antagonistic receptor signaling events is enigmatic. Using superresolution optical microscopy, Lopes et al. (2017. <jats:italic>J. Cell Biol.</jats:italic><jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="https://doi.org/10.1083/jcb.201608094" ext-link-type="uri">https://doi.org/10.1083/jcb.201608094</jats:ext-link>) demonstrate the nanometer-scale molecular reorganization of antagonistic signaling receptors in macrophages, after engagement by the receptors of activating and inhibitory ligands. They propose that large-scale rearrangements of this type underpin decision-making by these cells.</jats:p>