Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases
Thinnes CC., Tumber A., Yapp C., Scozzafava G., Yeh T., Chan MC., Tran TA., Hsu K., Tarhonskaya H., Walport LJ., Wilkins SE., Martinez ED., Müller S., Pugh CW., Ratcliffe PJ., Brennan PE., Kawamura A., Schofield CJ.
<p>A Betti reaction was used for efficient generation of 2OG oxygenase inhibitors, including for KDM4 demethylases.</p>