Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.
Skip to main content

The development of non-invasive methods to assess airway inflammation in asthma has made it possible to relate inflammation to other features of the disease in large and heterogeneous populations. Studies have shown that eosinophilic airway inflammation is not always present in asthma nor is it an exclusive feature of asthma. Moreover studies with humanised monoclonal antibodies to IL-5 have shown that eosinophilic airway inflammation can be disassociated from symptoms and disordered airway function. These features may be more closely linked to the presence of mast cells within the airway smooth muscle. Eosinophilic airway inflammation is associated with corticosteroid-responsive disease and there is increasing evidence that it is important in the genesis of asthma exacerbations. Thus it appears that different aspects of the lower airway inflammatory response are important in the genesis of the different manifestations of asthma.

Type

Journal article

Journal

CPD Bulletin Immunology and Allergy

Publication Date

01/01/2002

Volume

2

Pages

79 - 83