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A preliminary study of gag-specific, MHC-restricted CD8+ CTL has been performed in nine Gambian patients infected with HIV2. Such CTL were present in at least 55% of patients in fresh peripheral blood mononuclear cells without the requirement for in vitro restimulation. We have identified a nonamer peptide from HIV2 gag that is recognized by CD8+ HLA-B53 CTL using an amino acid sequence motif predicted from analysis of endogenous peptides eluted from HLA-B53 molecules. This peptide, from an HIV2/SIV conserved sequence, has previously been reported to be recognized by CTL from non-human primates vaccinated with recombinant vaccinia virus expressing the gag protein of SIV or infected with SIV virus. HLA-B53-restricted, HIV2 gag-specific CTL did not recognize target cells expressing HIV1 gag proteins, indicating that no cellular cross protection to HIV1 could be expected in this case.

Type

Journal article

Journal

J Immunol

Publication Date

15/09/1993

Volume

151

Pages

3361 - 3369

Keywords

Amino Acid Sequence, Cytotoxicity, Immunologic, Epitopes, Gambia, Gene Products, gag, HIV Infections, HIV Seropositivity, HIV-2, Humans, Immunity, Cellular, Major Histocompatibility Complex, Molecular Sequence Data, Peptides, Recombinant Proteins, T-Lymphocytes, Cytotoxic