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A concise and convergent synthesis of the atorvastatin, the best-selling cardiovascular drug of all time, is presented. Our approach is based on an Ugi reaction, which shortens the current synthetic route and is advantageous over the published syntheses.

Original publication

DOI

10.1021/acsmedchemlett.8b00579

Type

Journal article

Journal

ACS Medicinal Chemistry Letters

Publication Date

14/03/2019

Volume

10

Pages

389 - 392