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Circadian rhythms are evolutionarily conserved anticipatory systems that allow the host to prepare and respond to threats in its environment. This article summarizes a European Biological Rhythms Society (EBRS) workshop held in July 2020 to review current knowledge of the interplay between the circadian clock and viral infections to inform therapeutic strategies against SARS-CoV-2 and COVID-19. A large body of work supports the role of the circadian clock in regulating various aspects of viral replication, host responses, and associated pathogenesis. We review the evidence describing the multifaceted role of the circadian clock, spanning host susceptibility, antiviral mechanisms, and host resilience. Finally, we define the most pressing research questions and how our knowledge of chronobiology can inform key translational research priorities.

Original publication

DOI

10.1177/0748730420987669

Type

Journal article

Journal

Journal of biological rhythms

Publication Date

02/2021

Volume

36

Pages

23 - 34

Addresses

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Keywords

Immune System, Animals, Humans, Virus Replication, Circadian Rhythm, Host-Pathogen Interactions, Circadian Clocks, Pandemics, COVID-19, SARS-CoV-2